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Robert Sean Leonard, who portrays Wilson, said that House and his character—whose name is very similar to Watson's—were originally intended to work together much as Holmes and Watson do; in his view, House's diagnostic team has assumed that aspect of the Watson role.

Individual episodes of the series contain additional references to the Sherlock Holmes tales.

Hugh Laurie directed the 17th episode of season six, "Lockdown".

As a cost-cutting measure, the three actors were asked to accept reduced salaries.Epps and Leonard came to terms with the producers, but Edelstein did not, and in May 2011 it was announced that she would not be returning for the show's eighth season.Writers Eli Attie and Sean Whitesell joined the show at the start of season four; Attie would stay on the show's writing staff through the series finale, which he co-wrote.Since the beginning of season four, Moran, Friend, and Lerner have been credited as executive producers on the series, joining Attanasio, Jacobs, Shore, and Singer.The producers originally planned to recruit two new full-time actors, with Foreman, who returns in season four's fifth episode, bringing the team back up to three members; ultimately, the decision was made to add three new regular cast members.

(Along with Epps, actors Morrison and Spencer remained in the cast, as their characters moved on to new assignments.) During production, the show's writers dismissed a single candidate per episode; as a result, said Jacobs, neither the producers nor the cast knew who was going to be hired until the last minute. S.) "House" by Scott Donaldson and Richard Nolan (Europe, season 1 only) "House, M. Main Theme" by Jon Ehrlich and Leigh Roberts (International (from season 2 on), and Netflix) House (also called House, M.D.) is an American television medical drama that originally ran on the Fox network for eight seasons, from November 16, 2004 to May 21, 2012. Gregory House (Hugh Laurie), an unconventional, misanthropic medical genius who, despite his dependence on pain medication, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital (PPTH) in New Jersey.Paul Attanasio and Katie Jacobs, the heads of Heel and Toe Films; David Shore, the head of Shore Z Productions; and Bryan Singer, the head of Bad Hat Harry Productions, were executive producers of the program for its entirety. Moran joined the staff as writers at the beginning of the first season after the making of the pilot episode.Writers Doris Egan, Sara Hess, Russel Friend, and Garrett Lerner joined the team at the start of season two.The series' premise originated with Paul Attanasio, while David Shore, who is credited as creator, was primarily responsible for the conception of the title character.